There is variable penetrance and variable gene expression within these genetic mutations.
2.
SHM results in approximately one nucleotide change per variable gene, per cell division.
3.
Although stable and variable gene deserts differ in content and function, both wield conservatory abilities.
4.
Thus, the majority of gene deserts are variable gene deserts, which may have alternate functions.
5.
Therefore, shuffling may still occur before stabilizing regions within the variable gene deserts begin to cluster as whole units.
6.
Stable gene deserts have fewer repeats and have relatively higher Guanine to Cytosine ( GpC ) content than observed in variable gene deserts.
7.
A possible explanation for this phenomenon is that variable gene deserts may be recently evolved regions that have not yet been fixed into stable gene deserts.
8.
This research led to verification of the " two genes, one polypeptide " hypothesis and insights into the mechanisms responsible for the diversification of the immunoglobulin variable genes.
9.
The study underlined the great significance that structural variants, especially mCNVs, have on gene dosage which leads to variable gene expressions and human phenotypic diversity in the population.
10.
As a result, due to the prevalence of cytosine to thymine conversions, the most common SNP, would cause a gradual separation between the few essential genes within variable gene deserts.
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